Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 4/20 | 0.35 |
| ▸ | NQO1 | P15559 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675962 | 0.78 | PARP11 (0.50) | IDH1PARP11CALM1TACR3TACR1 | |
| SCHEMBL2879790 | 0.77 | NPC1 (0.39) | PDK2TSHR | |
| SCHEMBL27791814 | 0.77 | PARP11 (0.49) | IDH1PARP11CALM1TSHR | |
| SCHEMBL5713934 | 0.75 | CNR1 (0.38) | PDK2 | |
| SCHEMBL5713702 | 0.73 | GABRA1 (0.39) | TSHR | |
| SCHEMBL5713655 | 0.73 | ESR1 (0.36) | — | |
| SCHEMBL5714067 | 0.73 | HRH3 (0.42) | TSHR | |
| SCHEMBL5714220 | 0.72 | SKP2 (0.40) | — | |
| SCHEMBL5713715 | 0.70 | RELA (0.42) | PDK2HNF4A | |
| SCHEMBL19630481 | 0.69 | TSHR (0.50) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847006-A | Therapeutic guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0746316-A4 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0746316-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995014467-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-06-01 | — | — | WO | disclosed |