Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.65 |
| ▸ | MMP3 | P08254 | 3/20 | 0.65 |
| ▸ | ADAMTS5 | Q9UNA0 | 10/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NAT1 | P18440 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311453 | 1.00 | MMP13 (0.65) | MMP13MMP3ADAMTS5GSK3BPTP4A3 | |
| SCHEMBL27479994 | 0.86 | MEN1 (0.57) | MMP13ADAMTS5GSK3BPTP4A3CA2 | |
| SCHEMBL18102998 | 0.84 | NAT1 (0.59) | MMP13MMP3ADAMTS5PTP4A3CA2 | |
| SCHEMBL8171894 | 0.84 | NAT1 (0.59) | MMP13MMP3ADAMTS5PTP4A3CA2 | |
| SCHEMBL8708384 | 0.80 | PIM1 (0.61) | MMP13MMP3ADAMTS5GSK3BPTP4A3 | |
| SCHEMBL8310456 | 0.80 | PIM1 (0.61) | MMP13MMP3ADAMTS5GSK3BPTP4A3 | |
| SCHEMBL8307763 | 0.80 | NAT1 (0.61) | MMP13MMP3ADAMTS5PTP4A3CA2 | |
| SCHEMBL8713697 | 0.80 | NAT1 (0.61) | MMP13MMP3ADAMTS5PTP4A3CA2 | |
| SCHEMBL8308267 | 0.79 | MMP13 (1.00) | MMP13MMP3ADAMTS5GSK3BAKR1B1 | |
| SCHEMBL1248886 | 0.79 | MMP13 (1.00) | MMP13MMP3ADAMTS5GSK3BAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |