Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PTP4A3 | O75365 | 3/20 | 0.50 |
| ▸ | NAT1 | P18440 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | MAX | P61244 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708384 | 1.00 | PIM1 (0.61) | PIM1RAB9AMEN1KMT2APTP4A3 | |
| SCHEMBL8171894 | 0.83 | NAT1 (0.59) | PIM1MEN1KMT2APTP4A3NAT1 | |
| SCHEMBL18102998 | 0.83 | NAT1 (0.59) | PIM1MEN1KMT2APTP4A3NAT1 | |
| SCHEMBL8311453 | 0.80 | MMP13 (0.65) | PTP4A3NAT1CA2EPHX1ADAMTS5 | |
| SCHEMBL8714982 | 0.80 | MMP13 (0.65) | PTP4A3NAT1CA2EPHX1ADAMTS5 | |
| SCHEMBL8713697 | 0.78 | NAT1 (0.61) | PIM1RAB9AMEN1KMT2APTP4A3 | |
| SCHEMBL8307763 | 0.78 | NAT1 (0.61) | PIM1RAB9AMEN1KMT2APTP4A3 | |
| SCHEMBL8172015 | 0.77 | MYC (0.61) | PIM1RAB9APTP4A3NAT1CA2 | |
| SCHEMBL8166533 | 0.77 | NPC1 (0.54) | PIM1RAB9AMEN1KMT2ANAT1 | |
| SCHEMBL8173323 | 0.77 | CSNK2A2 (0.64) | PIM1RAB9AMEN1KMT2ANAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| CN-1091006-A | Chemical compound as blood sugar lowering and treatment degenerative brain disorder | LILLY CO ELI (US) | 1994-08-24 | — | — | CN | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |