Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714989 | 1.00 | DHODH (0.54) | DHODHALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL13524429 | 0.83 | DHODH (0.62) | DHODHALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6071705 | 0.80 | MEN1 (0.49) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL9206813 | 0.79 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL8718146 | 0.79 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8714895 | 0.79 | DHODH (0.69) | DHODHALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8716086 | 0.79 | DHODH (0.59) | DHODHALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL8714900 | 0.79 | DHODH (0.69) | DHODHALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8718151 | 0.79 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8716083 | 0.79 | DHODH (0.59) | DHODHALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538783-B1 | N-phenyl-2-cyano-3-hydroxycrotonic acid amid derivatives and their use as medicaments having immunomodulating properties | HOECHST AG (DE) | 1995-09-27 | — | — | EP | claimed |
| JP-5201948-A | — | — | None | — | — | JP | disclosed |
| US-5773470-A | TREATING RHEUMATIC DISEASES, AUTOIMMUNE DISEASES AND REJECTION REACTIONS DUE TO ORGAN TRANSPLANTING | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| US-5747664-A | N-Phenyl-2-cyano-3-hydroxycrotonamide derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-05 | — | — | US | disclosed |
| JP-H05201948-A | N-PHENYL-2-CYANO-3-HYDROXYCROTONAMIDE DERIVATIVE AND ITS USE AD MEDICAMENT HAVING IMMUNOREGULATABILITY | HOECHST AG | 1993-08-10 | — | — | JP | disclosed |