Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960854 | 0.84 | AR (0.56) | ALDH1A1TSHRLMNASMN1; SMN2MAPK1 | |
| SCHEMBL4960442 | 0.82 | MAPT (0.55) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL8714995 | 0.80 | DHODH (0.54) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL8714989 | 0.80 | DHODH (0.54) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL2929137 | 0.77 | ALDH1A1 (0.61) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL8718043 | 0.75 | ALDH1A1 (0.56) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL21555938 | 0.74 | ALDH1A1 (0.52) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL17100999 | 0.74 | ALDH1A1 (0.52) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL17100996 | 0.74 | ALDH1A1 (0.52) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL7125256 | 0.74 | DHODH (0.47) | MEN1KMT2ARAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | MEN1 3896/4885KMT2A 1686/4885RAB9A 3765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.