Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8715123 | 1.00 | ALDH1A1 (0.37) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL7759973 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL4698983 | 0.71 | TSHR (0.40) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL4698991 | 0.71 | ALDH1A1 (0.48) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL1389030 | 0.71 | TSHR (0.40) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL906226 | 0.71 | ALDH1A1 (0.40) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL1273983 | 0.69 | ALDH1A1 (0.33) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL1273980 | 0.69 | ALDH1A1 (0.33) | ALDH1A1TSHRSMN1; SMN2MAPTGAA | |
| SCHEMBL8088630 | 0.69 | — | — | |
| SCHEMBL11374341 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767082-A | ANTIFERTILITY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0277829-B1 | Nonapeptide and decapeptide analogs of LHRH as LHRH antagonists | SYNTEX INC (US) | 1994-07-27 | — | — | EP | disclosed |
| EP-0301850-A2 | LHRH antagonist analogs and 19-nor-progestational steroids for therapy | SYNTEX (U.S.A.) INC. (US) | 1989-02-01 | — | — | EP | disclosed |
| US-4801577-A | REPRODUCTION CONTROL | SYNTEX (U.S.A.) INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0277829-A2 | Nonapeptide and decapeptide analogs of LHRH as LHRH antagonists | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |