Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.36 |
| ▸ | HTR2B | P41595 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447054 | 0.93 | HTR2A (0.33) | HTR2CHTR2BHTR2AKDM4EALDH1A1 | |
| SCHEMBL4520961 | 0.93 | HTR2A (0.33) | HTR2CHTR2BHTR2AKDM4EALDH1A1 | |
| SCHEMBL26932098 | 0.81 | HTR2A (0.42) | HTR2CHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL18768219 | 0.81 | HTR2A (0.37) | HTR2CHTR2BHTR2AALDH1A1MAPT | |
| SCHEMBL31167218 | 0.80 | ALDH1A1 (0.34) | HTR2CHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL4148256 | 0.80 | HTR2A (0.44) | HTR2CHTR2BHTR2ATAAR1PRKDC | |
| SCHEMBL31566995 | 0.80 | HTR2A (0.44) | HTR2CHTR2BHTR2ATAAR1PRKDC | |
| SCHEMBL29283664 | 0.79 | ACLY (0.37) | HTR2CHTR2AKDM4EALDH1A1ACLY | |
| SCHEMBL15980355 | 0.79 | HTR2A (0.39) | HTR2CHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL18751319 | 0.77 | HTR2A (0.35) | HTR2CHTR2BHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |