Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 3/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24131214 | 0.93 | HDAC6 (0.38) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL221915 | 0.89 | MGLL (0.46) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL8716125 | 0.86 | MGLL (0.43) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL10816291 | 0.84 | MGLL (0.40) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL27596669 | 0.83 | HDAC6 (0.41) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL11264830 | 0.81 | MGLL (0.50) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL30372493 | 0.81 | MGLL (0.50) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL11252578 | 0.81 | MGLL (0.50) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL19224051 | 0.81 | MGLL (0.49) | MGLLPTGS1PTGS2FAAHCYP19A1 | |
| SCHEMBL24131221 | 0.81 | MGLL (0.42) | MGLLPTGS1PTGS2FAAHCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |