Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.46 |
| ▸ | FAAH | O00519 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596669 | 0.94 | HDAC6 (0.41) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL10816291 | 0.91 | MGLL (0.40) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL8716133 | 0.89 | MGLL (0.47) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL8716125 | 0.89 | MGLL (0.43) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL19224051 | 0.88 | MGLL (0.49) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL24131214 | 0.85 | HDAC6 (0.38) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL24122401 | 0.84 | HDAC6 (0.36) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL9879851 | 0.83 | MGLL (0.41) | MGLLFAAHPTGS1PTGS2HDAC6 | |
| SCHEMBL8892280 | 0.82 | MGLL (0.41) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL13204644 | 0.82 | MGLL (0.47) | MGLLFAAHPTGS1PTGS2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 333 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | claimed |
| US-20220186227-A1 | Therapeutic Targets for Oncogenic KRAS-Dependent Cancers | UNIVERSITY OF MASSACHUSETTS | 2022-06-16 | — | — | US | claimed |
| EP-3946629-A1 | THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS | University Of Massachusetts (US) | 2022-02-09 | — | — | EP | claimed |
| WO-2020198488-A1 | THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS | UNIVERSITY OF MASSACHUSETTS (US) | 2020-10-01 | — | — | WO | claimed |
| CN-108658869-A | Compound with anti-tumor activity and preparation method thereof and the purposes in pharmacy | 复旦大学 | 2018-10-16 | — | — | CN | claimed |
| EP-3329775-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | Medivation Prostate Therapeutics LLC (US) | 2018-06-06 | — | — | EP | claimed |
| US-9174943-B2 | Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2015-11-03 | — | — | US | claimed |
| CN-103108549-B | Method for synthesizing diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2015-09-09 | — | — | CN | claimed |
| WO-2015042170-A1 | COMPOSITIONS AND USES OF COMBINATIONS OF DIM-RELATED INDOLES AND SELECTED ANTI-ANDROGEN COMPOUNDS | WAYNE STATE UNIVERSITY (US) | 2015-03-26 | — | — | WO | claimed |
| CN-104341396-A | Diaryl hydantoin derivative, as well as preparation method, medicine composition and application thereof | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2015-02-11 | — | — | CN | claimed |
| EP-2646553-A1 | COMPOSITIONS AND METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS | Santaris Pharma A/S (DK) | 2013-10-09 | — | — | EP | claimed |
| US-20130190507-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS LLC | 2013-07-25 | — | — | US | claimed |
| CN-103108549-A | Method for synthesizing diarylthiohydantoin and diarylhydantoin compounds | MEDIVATION PROSTATE THERAPEUTICS INC | 2013-05-15 | — | — | CN | claimed |
| EP-2538785-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | Medivation Prostate Therapeutics, Inc. (US) | 2013-01-02 | — | — | EP | claimed |
| WO-2012065051-A1 | COMPOSITIONS AND METHODS FOR TREATING ANDROGEN RECEPTOR DEPENDENT DISORDERS INCLUDING CANCERS | ENZON PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | claimed |
| WO-2011106570-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | MEDIVATION PROSTATE THERAPEUTICS, INC. (US) | 2011-09-01 | — | — | WO | claimed |
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | disclosed |
| US-20240197701-A1 | ANDROGEN RECEPTOR INHIBITION TO TREAT SEPSIS AND SHOCK | APPLIED BIOLOGY, INC. | 2024-06-20 | — | — | US | disclosed |
| US-5122602-A | Optical indicators; medical diagnosis; quantitative analysis; immunoassay | MILES INC. (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0383092-A2 | Chromogenic merocyanine enzyme substrates | Bayer Corporation (US) | 1990-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190507-A1 | PROCESSES FOR THE SYNTHESIS OF DIARYLTHIOHYDANTOIN AND DIARYLHYDANTOIN COMPOUNDS | BPHL, PTMS, DHPS | MGLL 1156/4885FAAH 33/4885PTGS1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.