⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16427308 | 0.60 | — | — | |
| SCHEMBL15212831 | 0.53 | — | — | |
| SCHEMBL38440 | 0.50 | — | — | |
| SCHEMBL167008 | 0.47 | — | — | |
| SCHEMBL31083943 | 0.46 | — | — | |
| SCHEMBL31556353 | 0.46 | PDPK1 (0.56) | — | |
| Aminothiazole SCHEMBL1641818 | 0.45 | — | — | |
| Aminothiazole SCHEMBL5781624 | 0.45 | — | — | |
| SCHEMBL4842273 | 0.45 | — | — | |
| Hydrochloric Acid SCHEMBL3568548 | 0.45 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 672 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | claimed |
| EP-4188920-A1 | PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS | Tango Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | claimed |
| WO-2022026892-A1 | PIPERIDIN-1- YL-N-PYRYDI NE-3-YL-2-OXOACET AM IDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MT A-ACCUMULATING CANCERS | TANGO THERAPEUTICS, INC. (US) | 2022-02-03 | — | — | WO | claimed |
| US-10947242-B2 | [1,2,4]triazolo[1,5and#8208;A]pyrimidine compounds as PDE2 inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2021-03-16 | — | — | US | claimed |
| EP-3535267-B1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-30 | — | — | EP | claimed |
| EP-3080118-B1 | TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SRL (BE) | 2020-03-04 | — | — | EP | claimed |
| US-20190276462-A1 | [1,2,4]TRIAZOLO[1,5&#8208;A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-12 | — | — | US | claimed |
| EP-3535267-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2019-09-11 | — | — | EP | claimed |
| EP-3080115-B1 | FUSED IMIDAZOLE AND PYRAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2019-05-08 | — | — | EP | claimed |
| US-20140051689-A1 | Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2014-02-20 | — | — | US | claimed |
| JP-2007516983-A | — | — | 2007-06-28 | — | — | JP | claimed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | claimed |
| US-20070037974-A1 | Inhibitors of P2X3 | ROCHE PALO ALTO LLC | 2007-02-15 | — | — | US | claimed |
| CN-1898247-A | Polycyclic agents for the treatment of respiratory syncytial virus infection | BIOTA SCIENT MAN (AU) | 2007-01-17 | — | — | CN | claimed |
| EP-1697377-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 2006-09-06 | — | — | EP | claimed |
| EP-1430050-B1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005061513-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2005-07-07 | — | — | WO | claimed |
| US-20040242577-A1 | Piperdine derivatives and their use as modulators of chemokine (especially ccr3) activity | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | claimed |
| EP-1430050-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | AstraZeneca AB (SE) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024962-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF CHEMOKINE (ESPECIALLY CCR3) ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-27 | — | — | WO | claimed |