SCHEMBL8716306

SCHEMBL8716306

N#Cc1cccc(C(=O)O)c1C(=O)O.[Si]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
ALOX15 P16050 1/20 0.43
NOTUM Q6P988 1/20 0.41
HTT P42858 1/20 0.40
AKR1C3 P42330 1/20 0.39
CA12 O43570 3/20 0.39
CA1 P00915 3/20 0.39
CA2 P00918 3/20 0.39
CA7 P43166 3/20 0.39
CA9 Q16790 3/20 0.39
CA14 Q9ULX7 3/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
TAS2R14 Q9NYV8 2/20 0.38
TSHR P16473 1/20 0.38
NR4A1 P22736 1/20 0.38
NR4A2 P43354 1/20 0.38
NR4A3 Q92570 1/20 0.38
XDH P47989 1/20 0.38
SLC22A12 Q96S37 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27869030 0.98 ALDH1A1 (0.44) ALDH1A1ALOX15NOTUMHTTAKR1C3
Nitrous Acid SCHEMBL28878891 0.91 NOTUM (0.39) ALDH1A1ALOX15NOTUMHTTAKR1C3
SCHEMBL4849495 0.86 CA1 (0.46) NOTUMCA12CA1CA2CA7
SCHEMBL22890667 0.82 LRRK2 (0.47) ALDH1A1ALOX15NOTUMHTTCA12
SCHEMBL29740979 0.82 LRRK2 (0.47) ALDH1A1ALOX15NOTUMHTTCA12
SCHEMBL28226287 0.82 ALDH1A1 (0.48) ALDH1A1ALOX15AKR1C3CA12CA1
SCHEMBL5858945 0.80 ALDH1A1 (0.46) ALDH1A1ALOX15AKR1C3CA12CA1
SCHEMBL29365220 0.79 ALDH1A1 (0.56) ALDH1A1ALOX15HTTAKR1C3CA12
SCHEMBL180853 0.79 ALDH1A1 (0.56) ALDH1A1ALOX15HTTAKR1C3CA12
Water SCHEMBL713566 0.79 ALDH1A1 (0.60) ALDH1A1ALOX15AKR1C3CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0820489-A1 HYBRID PHTHALOCYANINE DERIVATIVES AND THEIR USES BIOSITE DIAGNOSTICS INC. (US) 1998-01-28 EP disclosed
EP-0670041-A4 FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS. BIOSITE DIAGNOSTICS INC (US) 1997-11-05 EP disclosed
EP-0670041-A1 FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS BIOSITE DIAGNOSTICS INC. (US) 1995-09-06 EP disclosed
WO-1995008772-A1 FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS BIOSITE DIAGNOSTICS INCORPORATED (US) 1995-03-30 WO disclosed