SCHEMBL4849495

SCHEMBL4849495

N#Cc1cccc(C#N)c1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
CA12 O43570 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
CXCR2 P25025 2/20 0.42
NOTUM Q6P988 3/20 0.41
TSHR P16473 1/20 0.39
MCL1 Q07820 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.37
FEN1 P39748 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
ESR2 Q92731 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27869030 0.87 ALDH1A1 (0.44) CA1CA2CA12CA7CA9
SCHEMBL4958909 0.87 CA12 (0.61) CA1CA2CA12CA7CA9
SCHEMBL8716306 0.86 ALDH1A1 (0.43) CA1CA2CA12CA7CA9
SCHEMBL7809866 0.86 TSHR (0.52) CA1CA2CA12CA7CA9
SCHEMBL11213853 0.86 CA1 (0.39) CA1CA2CA12CA7CA9
SCHEMBL22589590 0.86 CYP1A2 (0.42) CA1CA2CA12CA7CA9
SCHEMBL25264151 0.82 FOLH1 (0.49) KDM4EGAANOTUMESR2
SCHEMBL31212991 0.82 FOLH1 (0.49) KDM4EGAANOTUMESR2
Nitrous Acid SCHEMBL28878891 0.81 NOTUM (0.39) CA1CA2CA12CA7CA9
SCHEMBL27233073 0.80 TDP1 (0.58) CA1CA2TSHRL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7371866-B2 Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2008-05-13 US disclosed
WO-2005063385-A1 METHOD FOR OXIDIZING SATURATED HYDROCARBONS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2005-07-14 WO disclosed
US-20030216577-A1 Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) 2003-11-20 US disclosed
EP-1362840-A1 Process for the preparation of aromatic and heteroaromatic carboxylic acids via catalytic ozonolysis DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2003-11-19 EP disclosed