Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29205327 | 0.83 | PABPC1 (0.32) | KEAP1NFE2L2USP2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29117340 | 0.81 | PABPC1 (0.32) | MEN1KMT2AHPGDPABPC1SMN1; SMN2 | |
| SCHEMBL29205328 | 0.79 | ALDH1A1 (0.31) | MEN1KMT2AHPGDMAPTPABPC1 | |
| SCHEMBL9868390 | 0.78 | MEN1 (0.43) | KEAP1NFE2L2USP2MEN1KMT2A | |
| SCHEMBL9868384 | 0.78 | MEN1 (0.43) | KEAP1NFE2L2USP2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29117341 | 0.78 | ALDH1A1 (0.31) | MAPTPABPC1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4981713 | 0.75 | PABPC1 (0.32) | PABPC1 | |
| SCHEMBL6155027 | 0.75 | KDM4E (0.34) | MEN1KMT2AHPGDKDM4EMAPT | |
| Bromide SCHEMBL6154947 | 0.73 | KDM4E (0.33) | KMT2AHPGDKDM4EMAPTRAB9A | |
| SCHEMBL8843195 | 0.72 | KDM4E (0.40) | HPGDKDM4EMAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847006-A | Therapeutic guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0746316-A4 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0746316-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995014467-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-06-01 | — | — | WO | disclosed |