Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716493 | 1.00 | KDM4E (0.41) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL8709612 | 0.85 | TLR7 (0.42) | KDM4EALDH1A1TLR7SCN8ASCN10A | |
| SCHEMBL8709608 | 0.85 | TLR7 (0.42) | KDM4EALDH1A1TLR7SCN8ASCN10A | |
| SCHEMBL8713451 | 0.80 | ELANE (0.34) | KDM4ECYP2C19TLR7TBXA2RCNR2 | |
| SCHEMBL8713450 | 0.80 | ELANE (0.34) | KDM4ECYP2C19TLR7TBXA2RCNR2 | |
| SCHEMBL8709311 | 0.74 | ALDH1A1 (0.34) | KDM4EALDH1A1TLR7MAPTHTT | |
| SCHEMBL8709309 | 0.74 | ALDH1A1 (0.34) | KDM4EALDH1A1TLR7MAPTHTT | |
| SCHEMBL8709643 | 0.72 | MEN1 (0.35) | KDM4EALDH1A1HPGDCYP2C19TLR7 | |
| SCHEMBL8714961 | 0.71 | TLR7 (0.36) | KDM4ECYP2C19TLR7RXRA | |
| SCHEMBL8714957 | 0.71 | TLR7 (0.36) | KDM4ECYP2C19TLR7RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |