Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711340 | 0.94 | HTR2A (0.49) | HSD11B1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8711004 | 0.89 | HSD11B1 (0.60) | HSD11B1MGLLHTR2ACCR5POLB | |
| SCHEMBL8711216 | 0.89 | HSD11B1 (0.62) | HSD11B1MGLLHTR2ACCR5HTR2C | |
| SCHEMBL8711674 | 0.88 | HSD11B1 (0.54) | HSD11B1MGLLHTR2ACCR5HTR2C | |
| SCHEMBL8711020 | 0.87 | HSD11B1 (0.58) | HSD11B1MGLLHTR2ACCR5HTR2C | |
| SCHEMBL8713336 | 0.87 | HSD11B1 (0.45) | HSD11B1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL9232680 | 0.87 | HSD11B1 (0.56) | HSD11B1MGLLHTR2AHTR2CHTR7 | |
| SCHEMBL8711227 | 0.85 | HTR2A (0.46) | HSD11B1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8710884 | 0.84 | HTR1F (0.51) | HSD11B1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8714509 | 0.83 | HSD11B1 (0.51) | HSD11B1HTR2AHTR2CHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |