Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871660 | 1.00 | PDE4B (0.40) | PDE4BSIRT1AVPR1BPRKAA2CYP3A4 | |
| SCHEMBL872060 | 0.94 | PDE4B (0.40) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL872059 | 0.94 | PDE4B (0.40) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL871975 | 0.91 | PDE4B (0.41) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL871976 | 0.91 | PDE4B (0.41) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL871792 | 0.91 | SIRT1 (0.38) | PDE4BSIRT1AVPR1BCYP3A4 | |
| SCHEMBL871791 | 0.91 | SIRT1 (0.38) | PDE4BSIRT1AVPR1BCYP3A4 | |
| SCHEMBL870708 | 0.91 | PDE4B (0.41) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL870707 | 0.91 | PDE4B (0.41) | PDE4BAVPR1BPRKAA2CYP3A4 | |
| SCHEMBL872226 | 0.90 | PDE4B (0.48) | PDE4BAVPR1BPRKAA2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885SIRT1 552/4885AVPR1B 1234/4885 |
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885SIRT1 552/4885AVPR1B 1234/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | PDE4B 2/4885SIRT1 712/4885AVPR1B 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.