Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9332312 | 0.85 | KDM4E (0.39) | KDM4EALOX15TSHRSIRT1L3MBTL1 | |
| SCHEMBL2677144 | 0.78 | SMN1; SMN2 (0.45) | KDM4EALOX15TSHRSIRT1L3MBTL1 | |
| SCHEMBL2149851 | 0.76 | MEN1 (0.41) | KDM4EL3MBTL1KMT2AHTTALDH1A1 | |
| SCHEMBL14067662 | 0.76 | SMN1; SMN2 (0.44) | KDM4ETSHRL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL2676981 | 0.75 | ALDH1A1 (0.42) | KDM4EALOX15TSHRSIRT1KMT2A | |
| SCHEMBL2149770 | 0.74 | THRB (0.40) | KDM4EALOX15TSHRSIRT1L3MBTL1 | |
| SCHEMBL9332389 | 0.74 | KMT2A (0.39) | KDM4EALOX15TSHRSIRT1KMT2A | |
| SCHEMBL2676919 | 0.72 | GAA (0.44) | ALOX15L3MBTL1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL29848737 | 0.71 | NPC1 (0.42) | KDM4EALOX15TSHRSIRT1KMT2A | |
| SCHEMBL4436383 | 0.71 | KMT2A (0.39) | KDM4ETSHRKMT2ASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726200-A | Pro-drugs for CCK antagonists | WARNER-LAMBERT COMPANY (US) | 1998-03-10 | — | — | US | disclosed |
| US-5554643-A | Pro-drugs for CCK antagonists | WARNER-LAMBERT COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5340825-A | Pro drugs for CCK antagonists | WARNER-LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0546108-A4 | PRO-DRUGS FOR CCK ANTAGONISTS | — | 1993-09-22 | — | — | EP | disclosed |
| EP-0546108-A1 | PRO-DRUGS FOR CCK ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992004038-A1 | PRO-DRUGS FOR CCK ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |