Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | MAPT | P10636 | 10/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716684 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL8713370 | 0.85 | MAPT (0.66) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL8713366 | 0.85 | MAPT (0.66) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL19051320 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL31152149 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL20591067 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL20591066 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL8717977 | 0.83 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL8717976 | 0.83 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL8715157 | 0.82 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | claimed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | claimed |
| US-5783575-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | disclosed |
| US-5696148-A | POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | disclosed |