Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871672 | 1.00 | METAP2 (0.40) | METAP2CNR2PDE4BCYP3A4CYP2C9 | |
| SCHEMBL872270 | 0.93 | PDE4B (0.42) | METAP2CNR2PDE4BCYP3A4CYP2C9 | |
| SCHEMBL872271 | 0.93 | PDE4B (0.42) | METAP2CNR2PDE4BCYP3A4CYP2C9 | |
| SCHEMBL871669 | 0.91 | PDE4B (0.34) | CNR2PDE4BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL871670 | 0.91 | PDE4B (0.34) | CNR2PDE4BCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL872002 | 0.88 | METAP2 (0.36) | METAP2PDE4BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL872001 | 0.88 | METAP2 (0.36) | METAP2PDE4BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL870618 | 0.87 | PDE4B (0.40) | CNR2PDE4BKCNH2CNR1 | |
| SCHEMBL870619 | 0.87 | PDE4B (0.40) | CNR2PDE4BKCNH2CNR1 | |
| SCHEMBL3029268 | 0.86 | PDE4B (0.43) | METAP2CNR2PDE4BCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | METAP2 3123/4885CNR2 2229/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.