Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 8/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | F5 | P12259 | 1/20 | 0.31 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872001 | 1.00 | METAP2 (0.36) | METAP2P2RY1KCNH2F10F2 | |
| SCHEMBL870532 | 0.93 | PDE4B (0.38) | KCNH2PDE4BCYP3A4CYP2C19TNF | |
| SCHEMBL870531 | 0.93 | PDE4B (0.38) | KCNH2PDE4BCYP3A4CYP2C19TNF | |
| SCHEMBL872979 | 0.89 | PDE4B (0.35) | P2RY1KCNH2PDE4BTNFPDE4D | |
| SCHEMBL872980 | 0.89 | PDE4B (0.35) | P2RY1KCNH2PDE4BTNFPDE4D | |
| SCHEMBL869679 | 0.89 | MGLL (0.34) | NFE2L2PDE4BCYP1A2CYP3A4TSHR | |
| SCHEMBL869678 | 0.89 | MGLL (0.34) | NFE2L2PDE4BCYP1A2CYP3A4TSHR | |
| SCHEMBL871465 | 0.89 | TNF (0.34) | PDE4BCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL871464 | 0.89 | TNF (0.34) | PDE4BCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL871671 | 0.88 | METAP2 (0.40) | METAP2KCNH2F10PDE4BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | METAP2 3123/4885P2RY1 543/4885KCNH2 3141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.