Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826492 | 0.85 | POLB (0.52) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL8716978 | 0.81 | UGCG (0.41) | POLBSMN1; SMN2ALDH1A1MITFLMNA | |
| SCHEMBL9130644 | 0.81 | POLB (0.49) | KDM4EPOLBALDH1A1HIF1AKMT2A | |
| SCHEMBL8720249 | 0.80 | ALDH1A1 (0.46) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL8719808 | 0.79 | OPRK1 (0.46) | KDM4EOPRM1OPRD1OPRK1 | |
| SCHEMBL8716961 | 0.75 | KDM4E (0.51) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL10256789 | 0.75 | SMN1; SMN2 (0.64) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL13343048 | 0.75 | HRH3 (0.51) | KDM4EPOLBALDH1A1LMNAHRH3 | |
| SCHEMBL14069127 | 0.74 | KDM4E (0.50) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF | |
| SCHEMBL2168032 | 0.73 | KDM4E (0.56) | KDM4EPOLBSMN1; SMN2ALDH1A1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5532266-A | Acrylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5472961-A | Acetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-12-05 | — | — | US | disclosed |
| EP-0670318-A2 | Acetamides with analgesic and neuroprotective activity | MERCK PATENT GmbH (DE) | 1995-09-06 | — | — | EP | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |