Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 11/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163451 | 1.00 | ACACB (0.45) | ACACBF2GAAF10PLAT | |
| SCHEMBL8717134 | 0.89 | ACACB (0.44) | ACACBF2F10PLATPLG | |
| SCHEMBL7302360 | 0.86 | ACACB (0.45) | ACACBF2GAAF10PLAT | |
| SCHEMBL7303910 | 0.85 | ACACB (0.43) | ACACBF2GAAF10PLAT | |
| SCHEMBL7332989 | 0.84 | F2 (0.47) | ACACBF2F10PLATPLG | |
| SCHEMBL8947773 | 0.83 | GAA (0.40) | ACACBF2GAAF10PLAT | |
| SCHEMBL7332615 | 0.83 | F2 (0.49) | F2F10PLATPLGPRSS1 | |
| SCHEMBL8719583 | 0.82 | F2 (0.48) | F2F10PLATPLGPRSS1 | |
| SCHEMBL7326146 | 0.81 | GAA (0.45) | ACACBF2GAAPLATPLG | |
| SCHEMBL8716864 | 0.81 | GAA (0.45) | ACACBF2GAAPLATPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763604-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5677448-A | CHEMICAL INTERMEDIATES FOR MAKING ANTAGONIST OF THROMBIN, TREATING THROMBOSIS, STROKE, INFLAMMATION, ARTERIOSCLEROSIS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5578594-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5405854-A | Anticoagulants | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |