Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8719815 | 0.82 | OPRK1 (0.46) | TSHRKDM4EPOLBGAAMAPK1 | |
| SCHEMBL8716961 | 0.79 | KDM4E (0.51) | KDM4EPOLB | |
| SCHEMBL6491408 | 0.78 | HRH3 (0.50) | OPRK1 | |
| SCHEMBL6491412 | 0.78 | HRH3 (0.50) | OPRK1 | |
| SCHEMBL7676784 | 0.78 | HRH3 (0.50) | OPRK1 | |
| SCHEMBL9510568 | 0.75 | ACHE (0.48) | TSHRKDM4EOPRK1 | |
| SCHEMBL9510573 | 0.75 | ACHE (0.48) | TSHRKDM4EOPRK1 | |
| SCHEMBL9831262 | 0.72 | KDM4E (0.64) | TSHRKDM4EPOLBGAAAPLNR | |
| SCHEMBL28191688 | 0.71 | KDM4E (0.63) | TSHRKDM4EPOLBGAAAPLNR | |
| Hydrochloric Acid SCHEMBL28901933 | 0.68 | CYP2D6 (0.72) | CYP2D6APLNRMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5532266-A | Acrylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |