Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CDC42 | P60953 | 1/20 | 0.43 |
| ▸ | RAC1 | P63000 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8719156 | 1.00 | KDM4E (0.47) | KDM4EHPGDSAKR1C3AKR1C2PTGS1 | |
| SCHEMBL9503968 | 0.85 | CNR1 (0.49) | KDM4EAKR1C3AKR1C2PTGS1MAPT | |
| SCHEMBL30577887 | 0.85 | KDM4E (0.53) | KDM4EAKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL7332434 | 0.85 | KDM4E (0.53) | KDM4EAKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL8722216 | 0.85 | KDM4E (0.46) | KDM4EAKR1C3AKR1C2PTGS1MAPT | |
| SCHEMBL8722226 | 0.85 | TDP1 (0.52) | KDM4EAKR1C3AKR1C2PTGS1MAPT | |
| SCHEMBL8722223 | 0.85 | TDP1 (0.52) | KDM4EAKR1C3AKR1C2PTGS1MAPT | |
| SCHEMBL8591431 | 0.84 | MAPT (0.54) | MAPTALDH1A1LMNAALOX15APEX1 | |
| SCHEMBL8859936 | 0.81 | FLT3 (0.41) | KDM4EAKR1C3AKR1C2PTGS1MAPT | |
| SCHEMBL11313823 | 0.80 | KDM4E (0.44) | KDM4EAKR1C3AKR1C2PTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750764-A | Synthesis and resolution of propionic acid derivatives | AECI LIMITED (ZA) | 1998-05-12 | — | — | US | disclosed |
| WO-1997019048-A1 | SYNTHESIS OF PROPIONIC ACID DERIVATIVES | AECI LIMITED (ZA) | 1997-05-29 | — | — | WO | disclosed |