Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CDC42 | P60953 | 1/20 | 0.46 |
| ▸ | RAC1 | P63000 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722223 | 1.00 | TDP1 (0.52) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL8719156 | 0.85 | KDM4E (0.47) | TDP1PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL8719159 | 0.85 | KDM4E (0.47) | TDP1PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL7332434 | 0.80 | KDM4E (0.53) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30577887 | 0.80 | KDM4E (0.53) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL8722216 | 0.80 | KDM4E (0.46) | L3MBTL1AKR1C3AKR1C2PTGS1CYP1A2 | |
| SCHEMBL8859936 | 0.79 | FLT3 (0.41) | TDP1L3MBTL1AKR1C3AKR1C2PTGS1 | |
| SCHEMBL17775051 | 0.75 | CYP17A1 (0.55) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9420901 | 0.74 | CYP1A2 (0.52) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL9503968 | 0.74 | CNR1 (0.49) | TDP1PTGS2AKR1C3AKR1C2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750764-A | Synthesis and resolution of propionic acid derivatives | AECI LIMITED (ZA) | 1998-05-12 | — | — | US | disclosed |