SCHEMBL8719659

SCHEMBL8719659

CNC(=O)c1ccc(/C=C/C(=O)C(N)c2cccn2-c2ccc(Cl)c(C(O[SiH](c3ccccc3)c3ccccc3)C(C)(C)C)c2Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 7/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7010306 0.84 BDKRB2 (0.55) BDKRB2
SCHEMBL7012781 0.79 BDKRB2 (0.46) BDKRB2
SCHEMBL7007333 0.79 BDKRB2 (0.46) BDKRB2
SCHEMBL7010294 0.78 BDKRB2 (0.47) BDKRB2
SCHEMBL7009652 0.75 BDKRB2 (0.47) BDKRB2
SCHEMBL6643336 0.73 BDKRB2 (0.54) BDKRB2
SCHEMBL6643344 0.73 BDKRB2 (0.54) BDKRB2
SCHEMBL7015387 0.72 BDKRB2 (0.61) BDKRB2
SCHEMBL7014258 0.71 BDKRB2 (0.73) BDKRB2
SCHEMBL7015070 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861243-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-02 EP disclosed
WO-1997011069-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-27 WO disclosed