Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NAMPT | P43490 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.60 |
| ▸ | ITK | Q08881 | 1/20 | 0.60 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123277 | 1.00 | DEGS1 (0.70) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL20284021 | 0.88 | DEGS1 (0.68) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL15706299 | 0.85 | DEGS1 (0.82) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL14014144 | 0.84 | DEGS1 (0.76) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL2233174 | 0.84 | DEGS1 (0.76) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL20284029 | 0.84 | ALDH1A1 (0.69) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL20284448 | 0.82 | DEGS1 (1.00) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL21522275 | 0.82 | DEGS1 (1.00) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL15560342 | 0.81 | DEGS1 (0.76) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT | |
| SCHEMBL16845366 | 0.81 | DEGS1 (0.76) | DEGS1ALDH1A1SMN1; SMN2LMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| WO-2010094029-A2 | ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | SI, STOM, SUCLA2 | DEGS1 1648/4885ALDH1A1 3839/4885SMN1; SMN2 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.