Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | CDC42 | P60953 | 1/20 | 0.49 |
| ▸ | RAC1 | P63000 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769512 | 0.98 | ABCB11 (0.60) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL9629972 | 0.98 | ABCB11 (0.60) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL14762411 | 0.95 | ABCB11 (0.64) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL9630941 | 0.89 | ABCB11 (0.68) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL12990705 | 0.87 | ABCB11 (0.48) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL14783480 | 0.86 | ABCB11 (0.69) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL29657138 | 0.85 | ALDH1A1 (0.46) | ABCB11MAPT | |
| SCHEMBL14783538 | 0.84 | ABCB11 (0.54) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL14783039 | 0.84 | ABCB11 (0.71) | ABCB11AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL28584500 | 0.83 | SLC2A1 (0.47) | ABCB11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750764-A | Synthesis and resolution of propionic acid derivatives | AECI LIMITED (ZA) | 1998-05-12 | — | — | US | disclosed |
| WO-1997019048-A1 | SYNTHESIS OF PROPIONIC ACID DERIVATIVES | AECI LIMITED (ZA) | 1997-05-29 | — | — | WO | disclosed |
| EP-0274146-B1 | PROCESS FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS | GIST-BROCADES N.V. (NL) | 1992-04-01 | — | — | EP | disclosed |
| EP-0205215-B1 | PROCESS FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS | GIST-BROCADES N.V. (NL) | 1990-08-08 | — | — | EP | disclosed |
| EP-0274146-A1 | Process for the preparation of 2-arylpropionic acids | GIST-BROCADES N.V. (NL) | 1988-07-13 | — | — | EP | disclosed |
| EP-0205215-A2 | Process for the preparation of 2-arylpropionic acids | GIST-BROCADES N.V. (NL) | 1986-12-17 | — | — | EP | disclosed |