Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27661294 | 0.88 | MEN1 (0.50) | MEN1KMT2AGABRPGABRDGABRA1 | |
| SCHEMBL9753906 | 0.84 | RHOA (0.53) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL11132312 | 0.83 | ALDH1A1 (0.41) | MAOAMEN1KMT2ABCHECES1 | |
| SCHEMBL703737 | 0.78 | MAOA (0.50) | MAOAMEN1KMT2ABCHECES1 | |
| SCHEMBL9145493 | 0.77 | MAOA (0.44) | MAOAMEN1KMT2ABCHECES1 | |
| SCHEMBL10783453 | 0.77 | MAOA (0.44) | MAOAMEN1KMT2ABCHECES1 | |
| SCHEMBL26339667 | 0.73 | ALDH1A1 (0.41) | MAOAMEN1KMT2ABCHECES1 | |
| SCHEMBL26337520 | 0.73 | NPC1 (0.45) | MAOAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL11068047 | 0.72 | ALDH1A1 (0.45) | MAOAMEN1KMT2AALDH1A1KDM4E | |
| Fluorene SCHEMBL29254259 | 0.69 | SRD5A2 (0.51) | MAOAGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5777114-A | Spiro heterocycle-imidazo 1,2-a!indeno 1,2-e!pyrazine!-4'-ones, preparation thereof and drugs containing same | RHONE-POULENC RORER S.A. (FR) | 1998-07-07 | — | — | US | disclosed |
| EP-0093049-B1 | DITHIINO (1,4) (2,3-C) PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1986-07-16 | — | — | EP | disclosed |