SCHEMBL8720514

SCHEMBL8720514

CN(C)c1cc(Oc2ccnc(Cl)c2)nc(S(C)(=O)=O)n1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NFE2L2 Q16236 1/20 0.33
TP53 P04637 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
BPTF Q12830 1/20 0.32
GLP1R P43220 1/20 0.32
ESR1 P03372 1/20 0.31
CHRNA7 P36544 1/20 0.31
GPR119 Q8TDV5 1/20 0.31
NR1H2 P55055 1/20 0.30
NR1H3 Q13133 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
PPARG P37231 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8720669 0.78 HTT (0.44) LMNASMN1; SMN2TP53ESR1MEN1
SCHEMBL8720519 0.77 KMT2A (0.36) LMNASMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL8723515 0.74 SLC6A2 (0.43) LMNASMN1; SMN2TP53KMT2A
SCHEMBL8720496 0.74 ALDH1A1 (0.50) LMNAMEN1KMT2A
SCHEMBL8723614 0.70 LOX (0.41)
SCHEMBL8721109 0.66 F2 (0.44) CYP1A2CYP2C9PPARG
SCHEMBL10882661 0.65 SMN1; SMN2 (0.37) SMN1; SMN2NFE2L2TP53NR1H2NR1H3
SCHEMBL8669893 0.64 ALDH1A1 (0.53) LMNAMEN1KMT2APPARG
SCHEMBL6883165 0.64 PTGS2 (0.46) LMNANFE2L2NR1H2NR1H3
SCHEMBL30700822 0.64 PTGS2 (0.46) LMNANFE2L2NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700391-B1 HERBICIDAL COMPOUNDS SHELL INT RESEARCH (NL) 1998-10-21 EP disclosed
US-5759956-A PYRAZINE CARBOXAMIDE DERIVATIVES AMERICAN CYANAMID COMPANY (US) 1998-06-02 US disclosed
EP-0700391-A1 HERBICIDAL COMPOUNDS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1996-03-13 EP disclosed
WO-1994027974-A1 HERBICIDAL COMPOUNDS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1994-12-08 WO disclosed