Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722426 | 0.92 | MAPK8 (0.36) | MAPK8MAPK10GFERCYP3A4CYP11B2 | |
| SCHEMBL8721596 | 0.77 | CYP11B1 (0.47) | CYP3A4CYP11B2CYP19A1CYP1A2CYP2D6 | |
| SCHEMBL8619287 | 0.72 | IDO1 (0.51) | GFERCYP3A4CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL8721409 | 0.72 | IDO1 (0.46) | MAPK8MAPK10CYP3A4CYP11B2CYP19A1 | |
| SCHEMBL10614052 | 0.70 | NOTUM (0.47) | MAPK8MAPK10CYP3A4CYP19A1CYP1A2 | |
| SCHEMBL3787426 | 0.70 | LMNA (0.47) | MAPK8MAPK10CYP3A4CYP11B2CYP19A1 | |
| SCHEMBL8724216 | 0.65 | CYP11B1 (0.42) | MAPK8MAPK10CYP3A4CYP11B2CYP19A1 | |
| SCHEMBL3785685 | 0.65 | MAPT (0.46) | MAPK8MAPK10CYP3A4CYP19A1MAPT | |
| SCHEMBL8724113 | 0.64 | CYP17A1 (0.42) | MAPK8MAPK10CYP3A4CYP11B2CYP1A2 | |
| SCHEMBL3253209 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998000430-A1 | IMIDAZOL DERIVATIVES USEFUL AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-08 | — | — | WO | disclosed |