Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722319 | 0.76 | MEN1 (0.42) | CYP11B1CYP11B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8724113 | 0.74 | CYP17A1 (0.42) | CYP11B1CYP11B2CYP3A4MAPK8MAPK10 | |
| SCHEMBL27457703 | 0.73 | MEN1 (0.60) | CYP11B1CYP11B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8721409 | 0.73 | IDO1 (0.46) | CYP11B1CYP11B2CYP3A4MAPK8MAPK10 | |
| SCHEMBL3787426 | 0.71 | LMNA (0.47) | CYP11B1CYP11B2CYP3A4MAPK8MAPK10 | |
| SCHEMBL10614052 | 0.71 | NOTUM (0.47) | CYP3A4MAPK8MAPK10CYP2A6CYP2C9 | |
| SCHEMBL7644186 | 0.71 | CYP3A4 (0.48) | CYP11B1CYP11B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8720894 | 0.71 | MAPK8 (0.33) | CYP3A4MAPK8MAPK10CYP2A6LMNA | |
| SCHEMBL27590600 | 0.69 | CYP3A4 (0.47) | CYP11B1CYP11B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL8724044 | 0.69 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP3A4CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998000430-A1 | IMIDAZOL DERIVATIVES USEFUL AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-08 | — | — | WO | disclosed |