Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.66 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.51 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.51 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.46 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.46 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523588 | 0.99 | PLA2G2C (0.64) | PLA2G2CPLA2G2DLPAR1LPAR3LPAR5 | |
| SCHEMBL10607739 | 0.93 | PLA2G2C (0.74) | PLA2G2CPLA2G2DLPAR1LPAR3LPAR5 | |
| SCHEMBL9496438 | 0.92 | LPAR3 (0.56) | PLA2G2CLPAR1LPAR3LPAR5CYP2C9 | |
| SCHEMBL14659956 | 0.84 | PRKCA (0.56) | LPAR1LPAR3LPAR5LPAR2LPAR6 | |
| Octane SCHEMBL5312682 | 0.84 | PLA2G2C (0.48) | PLA2G2CPLA2G2DLPAR1LPAR3 | |
| SCHEMBL7204294 | 0.84 | PRKCA (0.56) | LPAR1LPAR3LPAR5LPAR2LPAR6 | |
| SCHEMBL6254776 | 0.84 | PRKCA (0.56) | LPAR1LPAR3LPAR5LPAR2LPAR6 | |
| SCHEMBL10566721 | 0.83 | PRKD3 (0.50) | PLA2G2CLPAR1LPAR3LPAR5AKT1 | |
| SCHEMBL10884407 | 0.82 | PLA2G2C (0.75) | PLA2G2CPLA2G2DLPAR1LPAR3LPAR5 | |
| SCHEMBL4485528 | 0.82 | PLA2G2C (0.75) | PLA2G2CPLA2G2DLPAR1LPAR3LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827831-A | Lipid nucleotide analog prodrugs for oral administration | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-10-27 | — | — | US | disclosed |
| US-5744592-A | IMPROVING THE BIOAVAILABILITY AND ABSORPTION OF A DRUG THROUGH THE DIGESTIVE TRACT BY COVALENTLY BONDING THE DRUG AND A 1-O-OR-S-ALKYL-SN-GLYCERO-3-PHOSPHATE | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-04-28 | — | — | US | disclosed |
| US-5484809-A | ANTITUMOR | VESTAR, INC. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5411947-A | converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate derivatives; drugs such as AZT, cladribine, AICA-Riboside | VESTAR, INC. (US) | 1995-05-02 | — | — | US | disclosed |