SCHEMBL8723541

SCHEMBL8723541

CC[Si](C)(C)c1cccc(Br)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
MAPK1 P28482 1/20 0.41
GAA P10253 2/20 0.41
KDM1A O60341 1/20 0.37
RCOR1 Q9UKL0 1/20 0.37
TAAR1 Q96RJ0 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
RAB9A P51151 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HPGD P15428 1/20 0.36
C1S P09871 1/20 0.35
PARP1 P09874 1/20 0.35
NPC1 O15118 3/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8725840 0.83 ALDH1A1 (0.44) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL25403356 0.78 CYP1A2 (0.44) ALDH1A1MAPK1GAAL3MBTL1CYP1A2
SCHEMBL7455712 0.78 CYP1A2 (0.44) ALDH1A1MAPK1GAAL3MBTL1CYP1A2
SCHEMBL29945235 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1RAB9A
SCHEMBL783254 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1RAB9A
SCHEMBL23457112 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1RAB9A
SCHEMBL10928549 0.76 ALDH1A1 (0.46) ALDH1A1MAPK1GAATAAR1RAB9A
SCHEMBL79324 0.75 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2TSHR
SCHEMBL17937791 0.75 ALDH1A1 (0.40) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL28062813 0.75 ALDH1A1 (0.40) ALDH1A1MAPK1GAATAAR1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1188479-A Process for preparing 1-[3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives HOECHST MARION ROUSSEL INC (US) 1998-07-22 CN disclosed
US-5760267-A FROM 1-HALO-3-TRIALKYLSILYLBENZENES HOECHST MARION ROUSSEL INC. (US) 1998-06-02 US disclosed
EP-0833829-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
EP-0791001-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-08-27 EP disclosed
WO-1997000877-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-01-09 WO disclosed
EP-0749972-A1 A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives MERRELL PHARMACEUTICALS INC. (US) 1996-12-27 EP disclosed
WO-1996014322-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1996-05-17 WO disclosed
US-5486638-A DEHALOGENATION AND FORMATION OF SILYL BOND ON BENZENE RING MARION MERRELL DOW INC. (US) 1996-01-23 US disclosed