SCHEMBL8725840

SCHEMBL8725840

CC[Si](CC)(CC)c1cccc(Br)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
MAPK1 P28482 1/20 0.44
GAA P10253 1/20 0.43
TAAR1 Q96RJ0 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
C1S P09871 1/20 0.38
PARP1 P09874 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
GABRA1 P14867 2/20 0.37
GABRG2 P18507 2/20 0.37
GABRB3 P28472 2/20 0.37
GABRA5 P31644 2/20 0.37
GABRA3 P34903 2/20 0.37
IDO1 P14902 2/20 0.36
AGXT P21549 2/20 0.36
RAPGEF4 Q8WZA2 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8722480 0.85 L3MBTL1 (0.42) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL8723541 0.83 ALDH1A1 (0.41) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL8723550 0.82 CYP1A2 (0.41) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL28062705 0.78 ALDH1A1 (0.38) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL17937577 0.78 ALDH1A1 (0.38) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL17937587 0.77 ALDH1A1 (0.39) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL17937733 0.77 ALDH1A1 (0.39) ALDH1A1MAPK1GAATAAR1L3MBTL1
SCHEMBL23457112 0.76 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1C1S
SCHEMBL29945235 0.76 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1C1S
SCHEMBL783254 0.76 ALDH1A1 (0.48) ALDH1A1MAPK1GAATAAR1C1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1188479-A Process for preparing 1-[3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives HOECHST MARION ROUSSEL INC (US) 1998-07-22 CN disclosed
US-5760267-A FROM 1-HALO-3-TRIALKYLSILYLBENZENES HOECHST MARION ROUSSEL INC. (US) 1998-06-02 US disclosed
EP-0833829-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
EP-0791001-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-08-27 EP disclosed
WO-1997000877-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-01-09 WO disclosed
EP-0749972-A1 A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives MERRELL PHARMACEUTICALS INC. (US) 1996-12-27 EP disclosed
WO-1996014322-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1996-05-17 WO disclosed
US-5486638-A DEHALOGENATION AND FORMATION OF SILYL BOND ON BENZENE RING MARION MERRELL DOW INC. (US) 1996-01-23 US disclosed