SCHEMBL8723588

SCHEMBL8723588

O=C(c1nccnc1Oc1ccccc1C(F)(F)F)N1CCOCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.46
AKR1C3 P42330 1/20 0.45
P2RY1 P47900 2/20 0.42
LRRK2 Q5S007 1/20 0.42
ALDH1A1 P00352 1/20 0.42
POLB P06746 1/20 0.42
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TP53 P04637 1/20 0.41
HTR1A P08908 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
PKM P14618 1/20 0.41
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
FKBP1A P62942 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8725899 0.77 P2RY1 (0.48) P2RY1HTR1ASLC6A2SLC6A4SLC6A3
SCHEMBL8341105 0.76 P2RY1 (0.50) P2RY1L3MBTL1HTR1ASLC6A2SLC6A4
SCHEMBL8720565 0.73 MAPT (0.51) NPSR1P2RY1ALDH1A1HTR1ASLC6A2
SCHEMBL14803631 0.72 HSP90AA1 (0.51) NPSR1ALDH1A1ATML3MBTL1
SCHEMBL14803570 0.68 HSP90AA1 (0.47) ALDH1A1ATML3MBTL1NPC1RAB9A
SCHEMBL14051396 0.68 CYP3A4 (0.51) NPSR1LRRK2POLBTP53NR1H2
SCHEMBL17206945 0.68 PDE10A (0.49) AKR1C3ALDH1A1ATML3MBTL1PKM
SCHEMBL4123885 0.67 ALDH1A1 (0.49) NPSR1AKR1C3LRRK2ALDH1A1POLB
SCHEMBL15966071 0.66 NPSR1 (0.49) NPSR1ALDH1A1ATML3MBTL1TSHR
SCHEMBL4479895 0.66 SCD (0.49) P2RY1HTR1ASLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700391-B1 HERBICIDAL COMPOUNDS SHELL INT RESEARCH (NL) 1998-10-21 EP claimed