Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188508 | 0.82 | HRH3 (0.60) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL28629479 | 0.81 | HRH3 (0.55) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL8721626 | 0.81 | HRH3 (0.48) | HRH3HDAC6 | |
| SCHEMBL8723594 | 0.79 | HRH3 (0.44) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL5543937 | 0.79 | RAB9A (0.46) | — | |
| SCHEMBL5544578 | 0.76 | LPL (0.39) | — | |
| SCHEMBL7768079 | 0.76 | HRH3 (0.84) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL4471773 | 0.75 | HRH3 (0.61) | HRH3HDAC8HDAC6BCHEACHE | |
| SCHEMBL7531410 | 0.73 | HRH3 (0.48) | HRH3HDAC8HDAC6PYCR1CNR2 | |
| SCHEMBL5543619 | 0.73 | HPGD (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |