Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723755 | 1.00 | CYP1A2 (0.43) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL19417358 | 0.83 | CYP1A2 (0.45) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL30366558 | 0.83 | CYP1A2 (0.45) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL18859387 | 0.73 | ALDH1A1 (0.46) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL5251847 | 0.73 | ALDH1A1 (0.42) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL5251840 | 0.73 | CYP1A2 (0.43) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL28769423 | 0.73 | CYP1A2 (0.39) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL7298514 | 0.73 | CYP1B1 (0.40) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL3575204 | 0.72 | CYP1A2 (0.45) | CYP1A2CYP1B1PARP1AHRALDH1A1 | |
| SCHEMBL29405395 | 0.72 | CYP1A2 (0.45) | CYP1A2CYP1B1PARP1AHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |