Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.36 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066427 | 0.80 | KMT2A (0.50) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL4553548 | 0.80 | KMT2A (0.50) | KMOELANEHDAC8RECQLNPC1 | |
| Oxalic Acid SCHEMBL14810479 | 0.76 | KMO (0.46) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL30730294 | 0.76 | NPC1 (0.42) | KMOELANEHDAC8NPC1RAB9A | |
| SCHEMBL14722845 | 0.76 | RECQL (0.39) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL18135255 | 0.75 | KMO (0.42) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL31326725 | 0.75 | KMO (0.42) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL20299508 | 0.73 | HDAC8 (0.46) | KMOELANEHDAC8RECQLNPC1 | |
| SCHEMBL18542560 | 0.72 | HDAC8 (0.58) | HDAC8 | |
| SCHEMBL878425 | 0.71 | RECQL (0.43) | KMOELANERECQLNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682009-B1 | Intermediate compounds for preparing endothelin-receptor antagonist triterpene derivatives | SHIONOGI & CO (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5587505-A | Triterpene derivatives and endothelin-receptor antagonists containing the same | SHIONOGI & CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0628569-B1 | Triterpene derivatives and endothelin-receptor antagonists containing the same | SHIONOGI & CO (JP) | 1996-09-11 | — | — | EP | disclosed |
| EP-0682009-A2 | Intermediate compounds for preparing endothelin-receptor antagonist triterpene derivatives | SHIONOGI & CO., LTD. (JP) | 1995-11-15 | — | — | EP | disclosed |
| US-5463107-A | Useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin | SHIONOGI & CO., LTD. (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0628569-A1 | Triterpene derivatives and endothelin-receptor antagonists containing the same | SHIONOGI & CO., LTD. (JP) | 1994-12-14 | — | — | EP | disclosed |