SCHEMBL8725815

SCHEMBL8725815

CSc1c(Cl)ccc(C(=O)C(C#N)C(=O)C2CC2)c1C

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8609547 0.87 HPGD (0.30) HPGDSMN1; SMN2
SCHEMBL8609420 0.85 USP2 (0.31) HPGD
SCHEMBL8726634 0.84 CTSK (0.33) SMN1; SMN2
SCHEMBL8607183 0.83
SCHEMBL8724264 0.82 MEN1 (0.32) HPGD
SCHEMBL8604618 0.80 EGFR (0.32)
SCHEMBL8607601 0.80 HPGD (0.40) HPGDSMN1; SMN2
SCHEMBL8953184 0.78 NOTUM (0.36)
SCHEMBL8607103 0.77 CTSK (0.35) SMN1; SMN2
SCHEMBL9239343 0.74 HPGD (0.32) HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0625508-B1 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-08-19 EP claimed
EP-0625508-A2 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 EP claimed
EP-0625508-B1 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-08-19 EP disclosed
EP-0625508-A2 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 EP disclosed