Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18461384 | 0.80 | HRH3 (0.36) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL7890511 | 0.79 | HRH3 (0.39) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL3807690 | 0.77 | HPGD (0.44) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL6142873 | 0.75 | CYP11B1 (0.38) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL11783876 | 0.75 | ALDH1A1 (0.38) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL18458915 | 0.75 | HRH3 (0.36) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL6488234 | 0.75 | AGXT (0.44) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL27983593 | 0.75 | HTR1D (0.37) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL5702537 | 0.73 | HRH3 (0.35) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D | |
| SCHEMBL14443342 | 0.73 | NOS3 (0.33) | HRH3RAPGEF4CYP11B1CYP11B2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |