Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MYOC | Q99972 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675749 | 0.93 | CXCL8 (0.68) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8729642 | 0.85 | CXCL8 (0.68) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL9031823 | 0.82 | HPGD (0.51) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7678128 | 0.82 | PTGS2 (0.59) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| Water SCHEMBL11373887 | 0.81 | HPGD (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7680742 | 0.80 | HPGD (0.52) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7678041 | 0.80 | CXCL8 (0.72) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732329 | 0.79 | CXCL8 (0.56) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL27370573 | 0.77 | HPGD (0.45) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8726546 | 0.77 | PTGS2 (0.67) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |