Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10755593 | 1.00 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL7742038 | 0.94 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL1361937 | 0.94 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL1360485 | 0.94 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL7743356 | 0.94 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL1361933 | 0.94 | DRD2 (0.56) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL16482975 | 0.86 | DRD2 (0.54) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL14545524 | 0.86 | DRD2 (0.54) | DRD2DRD3HTR1ACHRM2CHRM1 | |
| SCHEMBL11604206 | 0.81 | ADRA1A (0.62) | DRD2DRD3ANPEPADRA1AAADAT | |
| SCHEMBL11604211 | 0.81 | ADRA1A (0.62) | DRD2DRD3ANPEPADRA1AAADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835107-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1996038143-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |