SCHEMBL8726992

SCHEMBL8726992

CCCSc1c(Cl)ccc(C(=O)C(=COCC)C(=O)C2CC2)c1SC

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.32
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8725799 0.92 MAPT (0.32) MAPTHPGD
SCHEMBL8388430 0.92 MAPT (0.33) MAPTHPGD
SCHEMBL8391671 0.84
SCHEMBL7583366 0.83 LMNA (0.30)
SCHEMBL8754900 0.79 LMNA (0.31)
SCHEMBL8391862 0.79
SCHEMBL8488251 0.78 SLC6A4 (0.35) MAPT
SCHEMBL8488252 0.78 SLC6A4 (0.35) MAPT
SCHEMBL8754621 0.78 LMNA (0.34)
SCHEMBL6324660 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0625508-B1 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-08-19 EP disclosed
EP-0625508-A2 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 EP disclosed