Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732219 | 0.91 | PTGS1 (0.56) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL8732105 | 0.86 | AKR1B1 (0.50) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL17486795 | 0.85 | HDAC3 (0.48) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL8732035 | 0.84 | HDAC1 (0.50) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL8732100 | 0.83 | MAPT (0.50) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL10940661 | 0.81 | HDAC8 (0.56) | AKR1B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2237360 | 0.79 | PTGS2 (0.77) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL8731019 | 0.78 | PTGS2 (0.70) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL8729681 | 0.78 | PTGS2 (0.70) | PTGS1AKR1B1PTGS2CXCL8GLO1 | |
| SCHEMBL2237110 | 0.78 | PTGS2 (0.61) | PTGS1AKR1B1PTGS2CXCL8GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |