Sugi Predict

Sugi Predict / Compounds / SCHEMBL2237360

SCHEMBL2237360

SCHEMBL2237360

Cn1c(CC(=O)O)ccc1C(=O)c1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 3/20 0.77
▸ PTGS1 P23219 2/20 0.77
▸ AKR1B1 P15121 2/20 0.77
▸ CXCL8 P10145 1/20 0.77
▸ GLO1 Q04760 1/20 0.77
▸ HPGD P15428 2/20 0.56
▸ HDAC10 Q969S8 1/20 0.47
▸ ALDH1A1 P00352 3/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ LMNA P02545 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ ALOX12 P18054 1/20 0.45
▸ RECQL P46063 1/20 0.45
▸ ABCB11 O95342 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.41
▸ GLA P06280 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ SRC P12931 1/20 0.39
▸ BDKRB2 P30411 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8726561 0.97 PTGS2 (0.78) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8733716 0.93 PTGS2 (0.68) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8458232 0.91 PTGS1 (0.74) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8729681 0.88 PTGS2 (0.70) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8731019 0.88 PTGS2 (0.70) PTGS2PTGS1AKR1B1CXCL8GLO1
Tolmetin SCHEMBL11325188 0.87 PTGS2 (1.00) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL11807843 0.87 CXCL8 (0.60) PTGS2PTGS1AKR1B1CXCL8GLO1
Tolmetin SCHEMBL3150 0.87 PTGS2 (1.00) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8729642 0.87 CXCL8 (0.68) PTGS2PTGS1AKR1B1CXCL8GLO1
SCHEMBL8733265 0.87 PTGS2 (0.68) PTGS2PTGS1AKR1B1CXCL8GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1590314-B1 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DOMPÉ FARMACEUTICI S P A (IT) 2015-08-05 — — EP claimed
US-8871784-B2 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them DOMPE'S.P.A. (IT) 2014-10-28 — — US claimed
US-20100267726-A1 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DOMPE PHA.R.MA S.P.A. (IT) 2010-10-21 — — US claimed
EP-0051981-A1 Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids CALZADA Y CIA, S.R.C. (ES) 1982-05-19 — — EP claimed
US-11324828-B2 Hydrogel polymeric compositions and methods INCEPT, LLC (US) 2022-05-10 — — US disclosed
US-20190247504-A1 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS INCEPT LLC (US) 2019-08-15 — — US disclosed
US-10251954-B2 Hydrogel polymeric compositions and methods INCEPT, LLC (US) 2019-04-09 — — US disclosed
US-9775906-B2 Hydrogel polymeric compositions and methods INCEPT LLC (US) 2017-10-03 — — US disclosed
US-9775906-B2 Hydrogel polymeric compositions and methods INCEPT LLC (US) 2017-10-03 — — US disclosed
US-20160296623-A1 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS INCEPT, LLC 2016-10-13 — — US disclosed
US-20160296623-A1 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS INCEPT, LLC 2016-10-13 — — US disclosed
US-9370485-B2 Hydrogel polymeric compositions and methods INCEPT, LLC (US) 2016-06-21 — — US disclosed
US-4511575-A Antidiabetic pyrrolecarboxylic acids PFIZER INC. (US) 1985-04-16 — — US disclosed
US-4351843-A LOWERING BLOOD GLUCOSE PFIZER INC. (US) 1982-09-28 — — US disclosed
EP-0051981-A1 Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids CALZADA Y CIA, S.R.C. (ES) 1982-05-19 — — EP disclosed
EP-0051981-A1 Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids CALZADA Y CIA, S.R.C. (ES) 1982-05-19 — — EP disclosed
EP-0051981-A1 Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids CALZADA Y CIA, S.R.C. (ES) 1982-05-19 — — EP disclosed
US-4294760-A Preparation of 5-(arylcyanohydroxymethyl)-1-loweralkylpyrrole-2-acetic acid derivatives MCNEILAB, INC. (US) 1981-10-13 — — US disclosed
US-4282242-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1981-08-04 — — US disclosed
US-3952012-A MULTISTAGE MCNEIL LABORATORIES, INCORPORATED (US) 1976-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10251954-B2 Hydrogel polymeric compositions and methods CRYAA, CRYAB, UACA PTGS2 253/4885PTGS1 292/4885AKR1B1 4072/4885
US-11324828-B2 Hydrogel polymeric compositions and methods CRYAA, CRYAB, UACA PTGS2 253/4885PTGS1 292/4885AKR1B1 4072/4885
US-20160296623-A1 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS CRYAA, CRYAB, UACA PTGS2 253/4885PTGS1 292/4885AKR1B1 4072/4885
US-20100267726-A1 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM CXCR2, MMP8, CXCR1 PTGS2 124/4885PTGS1 128/4885AKR1B1 661/4885
US-20190247504-A1 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS CRYAA, CRYAB, UACA PTGS2 253/4885PTGS1 292/4885AKR1B1 4072/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.