Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 8/20 | 0.37 |
| ▸ | TRPM4 | Q8TD43 | 6/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27810098 | 0.84 | ESR1 (0.39) | ESR1LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL7360779 | 0.72 | TP53 (0.41) | TSHR | |
| SCHEMBL7370924 | 0.69 | PPARG (0.42) | LMNATSHRMAPK1 | |
| SCHEMBL4478957 | 0.66 | NQO2 (0.41) | TSHRMAPKAPK2ESR2 | |
| SCHEMBL700153 | 0.65 | TSHR (0.55) | TSHRSMN1; SMN2 | |
| SCHEMBL16766773 | 0.64 | PPARG (0.42) | LMNATSHRMAPK1 | |
| SCHEMBL19398219 | 0.64 | KMT2A (0.39) | TSHR | |
| SCHEMBL21243769 | 0.64 | ESR2 (0.38) | MAPK1NR1H2SMN1; SMN2MAPKAPK2ESR2 | |
| SCHEMBL21243773 | 0.64 | ESR2 (0.38) | MAPK1NR1H2SMN1; SMN2MAPKAPK2ESR2 | |
| SCHEMBL1202734 | 0.64 | ESR2 (0.38) | MAPK1NR1H2SMN1; SMN2MAPKAPK2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865439-A4 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0865439-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1996040672-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |