SCHEMBL8727693

SCHEMBL8727693

C=CCc1ccc(-c2ccc(COCC=CC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
CYP3A4 P08684 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TP53 P04637 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43
ALOX12 P18054 1/20 0.43
ALOX5 P09917 8/20 0.37
PPARG P37231 2/20 0.37
PPARD Q03181 2/20 0.37
PPARA Q07869 1/20 0.37
GABRA1 P14867 5/20 0.35
GABRB2 P47870 5/20 0.35
CNR2 P34972 5/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPK1 P28482 1/20 0.35
HSD17B10 Q99714 1/20 0.35
AR P10275 1/20 0.34
PTGS1 P23219 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8727690 1.00 ALDH1A1 (0.43) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727039 0.86 ALDH1A1 (0.42) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8730750 0.86 ALDH1A1 (0.42) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8730745 0.86 ALDH1A1 (0.42) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727041 0.86 ALDH1A1 (0.42) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8730874 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727939 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727087 0.84 ALDH1A1 (0.41) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727837 0.84 ALDH1A1 (0.41) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15
SCHEMBL8727093 0.84 ALDH1A1 (0.41) ALDH1A1CYP3A4SMN1; SMN2TP53ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882695-A1 BENZYL ETHER DERIVATIVES, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY CHISSO CORPORATION (JP) 1998-12-09 EP disclosed