SCHEMBL8730745

SCHEMBL8730745

C=CCc1ccc(-c2ccc(-c3ccc(COC/C=C/CC)cc3)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
CYP3A4 P08684 2/20 0.42
TP53 P04637 1/20 0.42
ALOX15 P16050 1/20 0.42
TSHR P16473 1/20 0.42
ALOX12 P18054 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PPARG P37231 2/20 0.36
PPARD Q03181 2/20 0.36
PPARA Q07869 1/20 0.36
GABRA1 P14867 7/20 0.35
GABRB2 P47870 7/20 0.35
CNR2 P34972 6/20 0.35
ALOX5 P09917 5/20 0.35
AR P10275 1/20 0.33
PTGS1 P23219 1/20 0.33
TRPM8 Q7Z2W7 1/20 0.33
IDO1 P14902 2/20 0.33
AGXT P21549 2/20 0.33
XDH P47989 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8730750 1.00 ALDH1A1 (0.42) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8727041 1.00 ALDH1A1 (0.42) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8727039 1.00 ALDH1A1 (0.42) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8727382 0.87 ALDH1A1 (0.39) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8727693 0.86 ALDH1A1 (0.43) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8727690 0.86 ALDH1A1 (0.43) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8731104 0.84 ALDH1A1 (0.34) ALDH1A1TP53ALOX5PTGS1IDO1
SCHEMBL8731107 0.84 ALDH1A1 (0.34) ALDH1A1TP53ALOX5PTGS1IDO1
SCHEMBL8727939 0.83 ALDH1A1 (0.46) ALDH1A1CYP3A4TP53ALOX15TSHR
SCHEMBL8730874 0.83 ALDH1A1 (0.46) ALDH1A1CYP3A4TP53ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882695-A1 BENZYL ETHER DERIVATIVES, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY CHISSO CORPORATION (JP) 1998-12-09 EP disclosed