Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6251433 | 0.81 | RAB9A (0.53) | TP53ALDH1A1KDM4ERAB9ACA1 | |
| SCHEMBL1086165 | 0.80 | ALDH1A1 (0.56) | TSHRTP53ALDH1A1KDM4ERAB9A | |
| SCHEMBL1086084 | 0.78 | ALDH1A1 (0.54) | TSHRTP53ALDH1A1KDM4ERAB9A | |
| SCHEMBL8764231 | 0.78 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL19663955 | 0.77 | RAB9A (0.50) | TSHRTP53ALDH1A1KDM4ERAB9A | |
| Terephthalic Acid SCHEMBL6664201 | 0.75 | TSHR (0.92) | TSHRTP53ALDH1A1SRD5A2CA1 | |
| Terephthalic Acid SCHEMBL5014892 | 0.75 | TSHR (0.92) | TSHRTP53ALDH1A1SRD5A2CA1 | |
| SCHEMBL4428955 | 0.75 | ALDH1A1 (0.50) | TSHRTP53ALDH1A1KDM4ERAB9A | |
| SCHEMBL25732307 | 0.75 | TSHR (0.48) | TSHRTP53ALDH1A1KDM4ERAB9A | |
| SCHEMBL11592117 | 0.75 | TSHR (0.60) | TSHRTP53ALDH1A1SRD5A2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753520-A | BIOCHEMICAL CONJUGATED WITH A HYDRAZINE OR A HYDRAZONE COMPOUND AS DRUG DELIVERY; HIGH BIOLOGICAL SPECIFICITY; MEDICINE FOR IMAGING, THERAPY, RADIOACTIVE TAGGING | JOHNSON MATTHEY INC. (US) | 1998-05-19 | — | — | US | disclosed |
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |